O uso tópico de probióticos para o tratamento da rosácea
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Abstract
A rosácea é uma doença de pele inflamatória crônica e acredita-se que seu mecanismo de ação, ainda que não comprovado, origina-se da desregulação do sistema imune inato, existindo outros fatores extrínsecos que podem desencadear o aumento dos sintomas. A mesma é dividida em quatro subtipos e cada um deles possui suas características: eritemato-telangiectasia, papulopústular, fimatosa e ocular. Através de estudos foi possível estabelecer uma relação entre a microbiota, tanto da pele quanto do intestino, onde verificou-se uma disbiose causada por essa doença. Esse desequilíbrio microbiano ocasionou estudos referentes ao uso de probióticos para o tratamento de doenças como a acne, rosácea, dermatite atópica e psoríase, atuando na redução dos processos inflamatórios de diferentes formas desde imunomodulação até proteção do microbioma.
O tratamento baseia-se no uso oral e tópico, e se faz importante analisar o microbioma dos pacientes, em razão de possuírem aspectos particulares que são definidos de acordo com fatores como: estresse, alimentação, consumo de álcool e uso de medicamentos. Analisando as ações dos probióticos na pele, seus mecanismos de ação e os possíveis benefícios, notou-se que a associação pode ser eficaz para o tratamento dessa doença, apresentando melhora dos sintomas e, consequentemente, da autoestima dos pacientes, juntamente com o crescimento pela busca de novas alternativas preventivas.
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References
Kolarsick PAJ, Kolarsick MA, Goodwin C. Anatomy and Physiology of the Skin. J Dermatol Nurses Assoc [Internet]. 2011 jul;3(4):203–13. Available from: http://journals.lww.com/01412499-201107000-00003
Khavkin J, Ellis DAF. Aging Skin: Histology, Physiology, and Pathology. Vol. 19, Facial Plastic Surgery Clinics of North America. 2011. p. 229–34.
Gilaberte Y, Prieto-Torres L, Pastushenko I, Juarranz Á. Anatomy and Function of the Skin. Em: Nanoscience in Dermatology. Elsevier Inc.; 2016. p. 1–14.
Kong HH, Segre JA. Skin microbiome: Looking back to move forward. Vol. 132, Journal of Investigative Dermatology. Nature Publishing Group; 2012. p. 933–9.
Byrd AL, Belkaid Y, Segre JA. The human skin microbiome. Vol. 16, Nature Reviews Microbiology. Nature Publishing Group; 2018. p. 143–55.
Dréno B, Araviiskaia E, Berardesca E, Gontijo G, Sanchez Viera M, Xiang LF, et al. Microbiome in healthy skin, update for dermatologists. Vol. 30, Journal of the European Academy of Dermatology and Venereology. Blackwell Publishing Ltd; 2016. p. 2038–47.
Rainer BM, Thompson KG, Antonescu C, Florea L, Mongodin EF, Bui J, et al. Characterization and Analysis of the Skin Microbiota in Rosacea: A Case–Control Study. Am J Clin Dermatol. 2020 fev 1;21(1):139–47.
Zaidi AK, Spaunhurst K, Sprockett D, Thomason Y, Mann MW, Fu P, et al. Characterization of the facial microbiome in twins discordant for rosacea. Vol. 27, Experimental Dermatology. Blackwell Publishing Ltd; 2018. p. 295–8.
Oge’ LK, Muncie HL, Phillips-Savoy AR. Rosacea: Diagnosis and Treatment [Internet]. Vol. 92. 2015. Available from: www.aafp.org/afp
Two AM, Wu W, Gallo RL, Hata TR. Rosacea: Part I. Introduction, categorization, histology, pathogenesis, and risk factors. Vol. 72, Journal of the American Academy of Dermatology. Mosby Inc.; 2015. p. 749–58.
van Zuuren EJ, Arents BWM, van der Linden MMD, Vermeulen S, Fedorowicz Z, Tan J. Rosacea: New Concepts in Classification and Treatment. Am J Clin Dermatol. 2021 jul 1;22(4):457–65.
Yu J, Ma X, Wang X, Cui X, Ding K, Wang S, et al. Application and mechanism of probiotics in skin care: A review. Vol. 21, Journal of Cosmetic Dermatology. John Wiley and Sons Inc; 2022. p. 886–94.
Habeebuddin M, Karnati RK, Shiroorkar PN, Nagaraja S, Asdaq SMB, Anwer MK, et al. Topical Probiotics: More Than a Skin Deep. Vol. 14, Pharmaceutics. MDPI; 2022.
França K, Frost P, Ther D. Topical Probiotics in Dermatological Therapy and Skincare: A Concise Review DIGITAL FEATURES. Dermatol Ther (Heidelb) [Internet]. 11. Available from: https://doi.org/10.6084/
Kim HS. Microbiota in Rosacea. Vol. 21, American Journal of Clinical Dermatology. Adis; 2020. p. 25–35.
Feldman SR, Huang WW, Huynh TT. Current Drug Therapies for Rosacea: A Chronic Vascular and Inflammatory Skin Disease [Internet]. Vol. 20, JMCP Journal of Managed Care Pharmacy. 2014. Available from: www.amcp.org
Egeberg A, Weinstock LB, Thyssen EP, Gislason GH, Thyssen JP. Rosacea and gastrointestinal disorders: a population-based cohort study. British Journal of Dermatology. 2017 jan 1;176(1):100–6.
Daou H, Paradiso M, Hennessy K, Seminario-Vidal L. Rosacea and the Microbiome: A Systematic Review. Vol. 11, Dermatology and Therapy. Adis; 2021.
Wollina U. Is rosacea a systemic disease? Clin Dermatol. 2019 nov 1;37(6):629–35.
Daou H, Paradiso M, Hennessy K, Seminario-Vidal L. Rosacea and the Microbiome: A Systematic Review. Vol. 11, Dermatology and Therapy. Adis; 2021.
Szántó M, Dózsa A, Antal D, Szabó K, Kemény L, Bai P. Targeting the gut-skin axis—Probiotics as new tools for skin disorder management? Exp Dermatol. 2019 nov 1;28(11):1210–8.
Knackstedt R, Knackstedt T, Gatherwright J. The role of topical probiotics in skin conditions: A systematic review of animal and human studies and implications for future therapies. Vol. 29, Experimental Dermatology. Blackwell Publishing Ltd; 2020. p. 15–21.
Yu Y, Dunaway S, Champer J, Kim J, Alikhan A. Changing our microbiome: probiotics in dermatology. Vol. 182, British Journal of Dermatology. Blackwell Publishing Ltd; 2020. p. 39–46.
Kim J, Ko Y, Park YK, Kim NI, Ha WK, Cho Y. Dietary effect of lactoferrin-enriched fermented milk on skin surface lipid and clinical improvement of acne vulgaris. Nutrition. 2010 set 1;26(9):902–9.
Olivares M, Castillejo G, Varea V, Sanz Y. Double-blind, randomised, placebo-controlled intervention trial to evaluate the effects of Bifidobacterium longum CECT 7347 in children with newly diagnosed coeliac disease. British Journal of Nutrition. 2014 jul 14;112(1):30–40.
Butler É, Lundqvist C, Axelsson J. Lactobacillus reuteri DSM 17938 as a novel topical cosmetic ingredient: A proof of concept clinical study in adults with atopic dermatitis. Microorganisms. 2020 jul 1;8(7):1–15.
Jung GW, Tse JE, Guiha I, Rao J. Prospective, randomized, open-label trial comparing the safety, efficacy, and tolerability of an acne treatment regimen with and without a probiotic supplement and minocycline in subjects with mild to moderate acne. Vol. 17, Journal of Cutaneous Medicine and Surgery. 2013. p. 114–22.
Yao S, Zhao Z, Wang W, Liu X. Bifidobacterium Longum: Protection against Inflammatory Bowel Disease. Vol. 2021, Journal of Immunology Research. Hindawi Limited; 2021.
Blanchet-Réthoré S, Bourdès V, Mercenier A, Haddar CH, Verhoeven PO, Andres P. Effect of a lotion containing the heat-treated probiotic strain Lactobacillus johnsonii NCC 533 on Staphylococcus aureus colonization in atopic dermatitis. Clin Cosmet Investig Dermatol. 2017 jul 3;10:249–57.
Bowe WP, Logan AC. Acne vulgaris, probiotics and the gut-brain-skin axis-back to the future? [Internet]. 2011. Available from: http://www.gutpathogens.com/content/3/1/1
Guéniche A, Bastien P, Ovigne JM, Kermici M, Courchay G, Chevalier V, et al. Bifidobacterium longum lysate, a new ingredient for reactive skin. Exp Dermatol. 2010 ago;19(8).
Rather IA, Bajpai VK, Huh YS, Han YK, Bhat EA, Lim J, et al. Probiotic Lactobacillus sakei proBio-65 extract ameliorates the severity of imiquimod induced psoriasis-like skin inflammation in a mouse model. Front Microbiol. 2018 maio 17;9(MAY).