Effects of oral administration of hyaluronic acid on skin aging: a review
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Abstract
Introduction: In the human body, the total hyaluronic acid (AH) content found is approximately 15g every 70kg and half is found in the skin more specifically between the dermis and epidermis. With the passing of the years, it is observed a decline of its endogenous production altering its volume, hydration, sustentation and elasticity, leaving the skin with a more aged aspect. Objective: To evaluate the impact of oral supplementation of hyaluronic acid on skin aging. Material and Method: A bibliographic review in the main health databases MEDLINE, LILACS and SCIELO was performed, using the descriptors in Health Sciences (DeCS): hyaluronic acid, skin and skin aging, in Portuguese and English, considering the last 5 years. Result: 51 studies were found, 5 were included and 46 excluded for not meeting the eligibility criteria. The observed studies suggest that the ingestion of AH by oral route increases hydration and decreases expression lines, being a possible treatment in the prevention of skin aging. Its use as an oral supplement is also relatively new compared to other nutrients used for dry skin and its aging. Conclusion: AH has improved the hydration and elasticity of the skin. In this review, the oral supplementation of different doses and molecular weights showed benefits in skin health. However, randomized clinical studies are necessary to confirm its effects and establish the ideal molecular weight, as well as the appropriate dose to minimize the clinical signs of skin aging.
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