Uso do ácido hialurônico no tratamento de sulcos nasolabiais evidenciados elo envelhecimento facial Uma revisão sistemática
Article Sidebar
Main Article Content
Abstract
Facial aging promotes progressive structural changes in the skin, muscles, and facial support tissues, contributing to the loss of elasticity, hydration, and facial volume, as well as to the appearance and deepening of nasolabial folds, popularly known as “smile lines”. These changes are related to the natural aging process and may also be influenced by genetic, environmental, and lifestyle factors. In this context, hyaluronic acid stands out as the main filler used in facial harmonization due to its biocompatibility, water retention capacity, safety, and high aesthetic effectiveness. This study aimed to analyze the use of hyaluronic acid in the treatment of nasolabial folds caused by facial aging, addressing anatomical aspects of the region, application techniques, material properties, benefits, limitations, and possible complications associated with the procedure. This is a systematic literature review carried out through the analysis of scientific articles published in national and international databases. The results demonstrated that hyaluronic acid filler is highly effective in restoring facial volume, improving skin hydration, promoting tissue support, and significantly softening nasolabial folds, providing natural results and high levels of aesthetic satisfaction among patients. In addition, the technique contributes to facial rejuvenation in a minimally invasive manner, with rapid recovery and immediate results. However, despite its benefits, the procedure requires in-depth anatomical knowledge, individualized assessment, and professional technical expertise, especially due to the vascular risks associated with the treated region, which may lead to complications such as edema, bruising, asymmetries, and, in more severe cases, tissue necrosis. It is concluded that hyaluronic acid filler represents a safe, effective, and widely used alternative for the treatment of nasolabial folds related to facial aging, provided that it is performed carefully, ethically, and individually, respecting the characteristics and needs of each patient.
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright Statement - Policy Proposal for Open Access Journals
Authors who publish in the Scientific Journal of Aesthetics & Cosmetology agree to the following terms: 1 - Authors retain the copyright and grant the journal the right to first publication, with the work simultaneously licensed under the Creative Commons Attribution License allowing the sharing of the work with acknowledgment of the authorship of the work and initial publication in this magazine. 2 - Authors are authorized to assume additional contracts separately, for non-exclusive distribution of the version of the work published in this journal (eg, publishing in institutional repository or as a book chapter), with acknowledgment of authorship and initial publication in this journal. 3 - Authors are allowed and encouraged to publish and distribute their work online (eg in institutional repositories or on their personal page) at any point before or during the editorial process, as this can generate productive changes, as well as increase the impact and citation of published work.
This is an open access article under the CC-BY license
(http://creativecommons.org/licenses/by/4.0)
References
Zargaran D, Zoller F, Zargaran A, Weyrich T, Mosahebi A. Facial skin ageing: Key concepts and overview of processes. Int J Cosmet Sci. 2022 Aug;44(4):414-420. doi: 10.1111/ics.12779. Epub 2022 Jul 8. PMID: 35426152; PMCID: PMC9543134.
Hong GW, Song S, Park SY, Lee SB, Wan J, Hu KS, Yi KH. Why Do Nasolabial Folds Appear? Exploring the Anatomical Perspectives and the Role of Thread-Based Interventions. Diagnostics. 2024;14(7):716. doi: 10.3390/diagnostics14070716.
Monheit G, Beer K, Hardas B, Grimes PE, Weichman BM, Lin V, Murphy DK. Safety and Effectiveness of the Hyaluronic Acid Dermal Filler VYC-17.5L for Nasolabial Folds: Results of a Randomized, Controlled Study. Dermatol Surg. 2018 May;44(5):670-678. doi: 10.1097/DSS.0000000000001529. PMID: 29701621; PMCID: PMC6221389.
Clark NW, Pan DR, Barrett DM. Facial fillers: Relevant anatomy, injection techniques, and complications. World J Otorhinolaryngol Head Neck Surg. 2023;9:227-235. doi:10.1002/wjo2.126.
Vasconcelos SCB, Nascente FM, Souza CMD, Rocha Sobrinho HM. O uso do ácido hialurônico no rejuvenescimento facial. RBMC Rev Bras Mil Ciências. 2020;6(14). doi: 10.36414/rbmc.v6i14.28
Cruz IP, Laranja MJ, Freitas MLP, Arêas GP. O uso do ácido hialurônico injetável na estética facial avançada. Vila Velha: Multivix; 2021.
Silva CLMC, Cavalcanti MMS, Silva WC. O uso de diferentes formas do ácido hialurônico na prevenção do envelhecimento facial [Trabalho de Conclusão de Curso]. Recife: Centro Universitário Brasileiro - UNIBRA; 2021.
Magri IO, De Maio M. Remodelamento do terço médio da face com preenchedores. Rev Bras Cir Plást. 2016;31(4):573-7. doi: 10.5935/2177-1235.2016RBCP0094.
Huang C, Liu J, Guo L, Liu Q, Song B. A Prospective Study Comparing the Efficacy of Hyaluronic Acid and Collagen in the Treatment of Nasolabial Folds. J Cosmet Dermatol. 2026 Jan;25(1):e70630. doi: 10.1111/jocd.70630. PMID: 41454456; PMCID: PMC12743174.
Lheritier C, Converset S, Rzany BJ, Cartier H, Ascher B. Efficacy of a New Hyaluronic Acid Dermal Filler on Nasolabial Folds Correction: A Prospective, Comparative, Double-Blinded Clinical Trial. Dermatol Surg. 2024 Aug 1;50(8):746-751. doi: 10.1097/DSS.0000000000004207. Epub 2024 May 7. PMID: 38713883; PMCID: PMC11288387.
Wanitphakdeedecha R, Ng JNC, Phumariyapong P, Nokdhes YN, Patthamalai P, Tantrapornpong P, Suphatsathienkul P, Ap inuntham C, Yan C, Nanchaipruek Y, Thongjaroensirikul P, Maneeprasopchoke P, Techapichetvanich T, Eimpunt h S, Manuskiatti W, Thanachaipiwat S, Panich U. A pilot study comparing the efficacy of autologous cultured fibroblast injections with hyaluronic acid fillers for treating nasolabial folds. Sci Rep. 2023 Apr 24;13(1):6616. doi: 10.1038/s41598-023-33786-9. PMID: 37095274; PMCID: PMC10126053.
Guo Y, Wei W, Wang H, Li Q, Wei C, Zhang J, Jin P. Effect of a New Hyaluronic Acid Hydrogel Dermal Filler Cross-Linked With Lysine Amino Acid for Skin Augmentation and Rejuvenation. Aesthet Surg J. 2023 Dec 14;44(1):NP87-NP97. doi: 10.1093/asj/sjad169. PMID: 37265096.
Li XZ, Chiang CF, Lin YH, Chen TM, Wang CH, Tzeng YS, Cui HY. Safety and efficacy of hyaluronic acid injectable filler in the treatment of nasolabial fold wrinkle: a randomized, double-blind, self-controlled clinical trial. J Dermatolog Treat. 2023 Dec;34(1):2190829. doi: 10.1080/09546634.2023.2190829. Epub 2023 Sep 11. PMID: 37694979.
Rzany B, Converset-Viethel S, Hartmann M, Larrouy JC, Ribé N, Sito G, Noize-Pin C. Efficacy and Safety of 3 New Resilient Hyaluronic Acid Fillers, Crosslinked With Decreased BDDE, for the Treatment of Dynamic Wrinkles: Results of an 18-Month, Randomized Controlled Trial Versus Already Available Comparators. Dermatol Surg. 2019 Oct;45(10):1304-1314. doi: 10.1097/DSS.0000000000001971. PMID: 31343447.
Chung C, Lee JH. A Single-Center, Randomized, Double-Blind Clinical Trial to Compare the Efficacy and Safety of a New Monophasic Hyaluronic Acid Filler and Biphasic Filler in Correcting Nasolabial Fold. Aesthetic Plast Surg. 2021 Dec;45(6):2902-2908. doi: 10.1007/s00266-021-02252-0. Epub 2021 Apr 13. PMID: 33851255.
Ascher B, Bayerl C, Kestemont P, Rzany B, Edwartz C, Podda M. A 12-Month Follow-up, Randomized Comparison of Effectiveness and Safety of Two Hyaluronic Acid Fillers for Treatment of Severe Nasolabial Folds. Dermatol Surg. 2017 Mar;43(3):389-395. doi: 10.1097/DSS.0000000000001031. PMID: 28005623; PMCID: PMC5414715.
Fino P, Toscani M, Grippaudo FR, Giordan N, Scuderi N. Randomized Double-Blind Controlled Study on the Safety and Efficacy of a Novel Injectable Cross-linked Hyaluronic Gel for the Correction of Moderate-to-Severe Nasolabial Wrinkles. Aesthetic Plast Surg. 2019 Apr;43(2):470-479. doi: 10.1007/s00266-018-1284-x. Epub 2019 Jan 3. PMID: 30607570.
Feng G, Peng T, Hong WJ, Zhang YL, Li G, Zheng W, Wang H, Luo SK. A Two-Center, Prospective, Randomized Controlled Trial to Evaluate the Efficacy and Safety of and Satisfaction with Different Methods of ART FILLER® UNIVERSAL Injection for Correcting Moderate to Severe Nasolabial Folds in Chinese Individuals. Aesthetic Plast Surg. 2023 Aug;47(4):1550- 1559. doi: 10.1007/s00266-023-03278-2. Epub 2023 Feb 21. PMID: 36810835.
Converset-Viethel S, Dobosz M, Baspeyras M, Skretkowicz-Szarmach K, Schlaudraff KU. Effectiveness and Safety of STYLAGE® L Lidocaine in the Treatment of Nasolabial Folds (NICE Study): A Randomized, Double-Blind, Split-Face Controlled Study. Aesthetic Plast Surg. 2025 Dec;49(24):6846-6857. doi: 10.1007/s00266-025-05105-2. Epub 2025 Aug 19. PMID: 40830240; PMCID: PMC12855380.
Lee JH, Kim SH, Park ES. The Efficacy and Safety of HA IDF Plus (with Lidocaine) Versus HA IDF (Without Lidocaine) in Nasolabial Folds Injection: A Randomized, Multicenter, Double- Blind, Split-Face Study. Aesthetic Plast Surg. 2017 Apr;41(2):422-428. doi: 10.1007/s00266-016- 0769-8. Epub 2016 Dec 28. Erratum in: Aesthetic Plast Surg. 2017 Apr;41(2):429. doi: 10.1007/s00266-017-0782-6. PMID: 28032168.
Ribeiro MR, Sommer AA, Andrade RS, Carvalho TA, Araújo MT, Pereira PC. Propriedades, eficácia e segurança do uso do ácido hialurônico em harmonização orofacial. Research, Society and Development. 2021;10(13):e286101321212.