Desenvolvimento de forma farmacêutica semissólida com ação anti-inflamatória para uso associado à drenagem linfática no tratamento do lipedema

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Published: Feb 23, 2026
DOI: https://doi.org/10.48051/rcec.v6i1.173
Keywords:
Keywords: Pharmaceutical technology; Lipedema; Cosmetic.

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Antonela Carvalho
Faculdade Pernambucana de Saúde
https://orcid.org/0009-0000-5003-0951
Renata Virginia Bezerra da Silva Silva
Faculdade Pernambucana de Saúde
https://orcid.org/0009-0002-0843-3831
Débora Dolores Souza da Silva Silva
Faculdade Pernambucana de Saúde
https://orcid.org/0000-0003-1903-2961
Flávia Patrícia Morais de Medeiros Medeiros
Faculdade Pernambucana de Saúde
https://orcid.org/0000-0002-2427-2727
Anna Carolina Teixeira Mesquita Mesquita
Faculdade Pernambucana de Saúde
https://orcid.org/0009-0001-6016-9399

Abstract

Lipedema is a chronic and progressive condition that predominantly affects women, characterized by the abnormal and symmetrical accumulation of subcutaneous adipose tissue, usually in the lower limbs, accompanied by pain, increased sensitivity, edema, and persistent inflammation. This condition directly interferes with the quality of life of patients, making diagnosis and appropriate clinical management difficult. Among the available therapeutic approaches, manual lymphatic drainage (MLD) stands out for helping to reduce discomfort and improve lymphatic circulation, promoting symptomatic relief and well-being. The association of this technique with topical formulations containing anti-inflammatory and toning active ingredients represents a promising strategy to enhance its effects, especially when combined with nanostructured approaches capable of optimizing the delivery of the active ingredients. This study aimed to develop and evaluate a cream formulation with anti-inflammatory and firming properties, intended for application during MLD in the dermato-functional care of patients with lipedema. This is a benchtop experimental study conducted at the Pernambuco Faculty of Health, with support from the University Pharmacy (Farma FPS), from July to September 2025. The formulation was developed using an oil-in-water (O/W) base with Polawax® (INCI: Cetearyl Alcohol (and) Polysorbate 60), incorporating the active ingredients Ginkgo biloba, hydroxyprolisilane (INCI: Methylsilanol Hydroxyproline Aspartate), and cafeisilane C (INCI: Caffeine (and) Siloxanetriol Alginate (and) Butylene Glycol), selected for their antioxidant, anti-inflammatory, and microcirculation-stimulating properties. Physicochemical, stability, and microbiological tests were conducted, ensuring the quality and safety of the product according to current regulatory standards. The results demonstrated that the formulation presented good stability, a homogeneous appearance, an adequate pH, and a pleasant texture, which facilitates its application during manual lymphatic drainage (MLD) procedures. Thus, the developed product proves to be a viable alternative for clinical use, contributing to the integration between pharmaceutical care and dermato-functional physiotherapy treatment in the management of lipedema.

Article Details

How to Cite
Carvalho, A., Silva, R. V. ., Silva, D. D. ., Medeiros, F. P. ., & Mesquita, A. C. (2026). Desenvolvimento de forma farmacêutica semissólida com ação anti-inflamatória para uso associado à drenagem linfática no tratamento do lipedema. Revista Científica De Estética & Cosmetologia, 6(1), E1732026 – 1. https://doi.org/10.48051/rcec.v6i1.173
Issue
Vol. 6 No. 1 (2026): Revista Científica de Estética e Cosmetologia "RCEC"
Section
CONTINUOUS FLOW ITEMS
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Author Biographies

Antonela Carvalho, Faculdade Pernambucana de Saúde

Undergraduate student in Pharmacy at the Pernambuco Faculty of Health (FPS), with active involvement in academic extension and research projects. Student representative of the Pharmacy program on the Internal Evaluation Committee (CPA) at FPS, and student coordinator of the Digital Resources in the Community Project at FPS. Works as a teaching assistant in the Anatomy and Models I and II laboratories at FPS. Has a strong interest in development and research.

   

Renata Virginia Bezerra da Silva Silva, Faculdade Pernambucana de Saúde

Undergraduate student in Pharmacy at the Pernambuco Faculty of Health (FPS), with experience in extension projects, research, and academic tutoring.

   

Débora Dolores Souza da Silva Silva, Faculdade Pernambucana de Saúde

Graduated in Pharmacy (2008) with qualifications in Biochemistry and Industry (2013) from the Federal University of Pernambuco (UFPE). Holds a Master’s degree (2017) in Pharmaceutical Sciences from the Graduate Program in Pharmaceutical Sciences (UFPE) and a PhD (2023) in Therapeutic Innovation from the Graduate Program in Therapeutic Innovation (UFPE). Currently works as a pharmacist at the Clinical Research Center of the Institute of Integral Medicine Prof. Fernando Figueira (IMIP), as a lecturer/tutor in the undergraduate Pharmacy program at the Pernambuco Faculty of Health (FPS), and as a member of the research group of the Laboratory of Drug Technology/UFPE.

   

Flávia Patrícia Morais de Medeiros Medeiros, Faculdade Pernambucana de Saúde

Graduated in Pharmacy with a qualification in Pharmaceutical Industry from the Federal University of Rio Grande do Norte (1998) and holds a Master’s degree in Pharmaceutical Sciences from the Federal University of Pernambuco (2001). Earned a PhD in 2010 from the Graduate Program of UFPE (Department of Pharmaceutical Sciences). She served as Research and Development Coordinator at the Pharmaceutical Laboratory of the State of Pernambuco (LAFEPE) from 2003 to March 2011. At LAFEPE, she also gained experience in the Solid Dosage Forms Production area, working in the supervision of the production of antipsychotics, antivirals, the antichagasic drug benznidazole, and oral supplements (vitamin C and vitamin C + vitamin D). Since 2023, she has been Head of the Cosmetics Division at LAFEPE. In the field of pharmaceutical education, she began collaborating in 1999 in the discipline of Drug Technology within the Industrial Pharmacy track at UFPE. In 2005, she taught the course on solid dosage forms at Universidade Potiguar (Natal), and in 2006 she taught a short course on Production Management at the Federal University of Sergipe (UFS). She supervises industry-based undergraduate research projects and participates as an examiner on thesis committees at several higher education institutions. She has also served as a collaborating researcher (without formal employment) at the Federal University of Pernambuco. Her main areas of expertise include technological development of medicines, quality control of medicines and raw materials, pharmaceutical dosage forms, good manufacturing practices, and the development and validation of methods and processes. Since 2010, she has been a faculty member at the Pernambuco Faculty of Health (FPS) and coordinates the Pharmacy program at this institution. She is a permanent faculty member of the Professional Master’s Program in Education for Health Teaching at FPS, participating in the module Methodology and Development of Research Projects in Education. She has been a member of the Education Committee of the Regional Pharmacy Council of Pernambuco (CRF-PE), within the Pharmaceutical Education Working Group, since 2012. She was an alternate member for Pernambuco of the Brazilian Association of Pharmaceutical Education (ABEF) from 2014 to 2016. She has also been a member of the Accessibility and Inclusion Center and the Faculty Development Committee at FPS, and is a member of the FPS Scientific Initiation Program Committee. She is a member of the Research Ethics Committee involving Human Subjects at IMIP (the teaching hospital of FPS) and serves as a backup pharmacist at the IMIP Clinical Research Center. She coordinates the FPS Extension Project “Rational Use of Medicines: Information Is the Best Medicine.” Completed supervisions include more than 15 undergraduate final projects (TCC), one FACEPE project (LAFEPE–UFPE), more than 10 Scientific Initiation projects (PIC/FPS and PIBIC/IMIP/CNPq), and more than 15 supervisions/co-supervisions in the Professional Master’s program. Ongoing activities include six supervisions in the Master’s Program in Health Education at FPS, one PIC/FPS project, and two PIBIC/CNPq–IMIP projects. She is also the coordinator of the Uniprofessional Residency Program in Pharmaceutical Industry at LAFEPE, under the Coremu of the Pernambuco School of Public Health – ESPPE/SES/PE.

Anna Carolina Teixeira Mesquita Mesquita, Faculdade Pernambucana de Saúde

Graduated in Pharmacy from the Pernambuco Faculty of Health IMIP in 2012. From 2009 to 2011, she carried out scientific initiation research in the area of pharmaceutics development of new pharmaceutical and cosmetic products, receiving an honorable mention award for the work developed and presented at the 7th IMIP Scientific Initiation Conference. In 2012, she conducted voluntary scientific initiation research in the Department of Biochemistry at the Keizo Asami Immunopathology Laboratory (LIKA), Federal University of Pernambuco (UFPE/PROPESQ), as a member of the Nanotechnology, Biotechnology and Cell Culture Research Group (NBC). She has experience as a hospital pharmacist with emphasis on Parenteral Nutrition (2013). In 2014, she joined the Therapeutic Innovation Graduate Program (PPGIT) at UFPE as a master’s student and worked as a research pharmacist at the Center for Quality Control of Medicines and Related Products (NCQMC). In 2016, she completed her Master’s degree in Therapeutic Innovation at the Federal University of Pernambuco (UFPE). She has experience as a pharmacist serving as technical manager of commercial establishments since 2013. Between 2017 and 2020, she was part of the team of pharmacists at Granado Pharmácias, holding the position of Assistant Technical Pharmacist. Currently (2023), she serves as coordinator of the university compounding pharmacy at the Pernambuco Faculty of Health (FPS) – FARMA FPS.

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