Efeitos anti-idade dos óleos essenciais de lavanda, alecrim e melaleuca em fibroblastos dérmicos humanos
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Abstract
Introduction: Skin aging is a multifactorial process that has great social importance. Over the years, the power to renew and fight free radicals in the local skin, resulting in a less effective skin barrier and greater damage to the dermis. The cosmetic industry has developed several products to slow down the process of this skin, in a more effective and less aggressive way to human beings and the environment, with plant-based actives. Among these actives, essential oils stand out due to the diversity of bioactives. Objectives: This study aimed to evaluate the influence of lavender, rosemary and tea tree essential oils on proliferation, expression of metalloproteinases and the synthesis of collagen and hyaluronic acid, in addition to the activity of collagenase in human dermal fibroblasts. Results: Lavender and rosemary essential oils have a potential effect in combating skin damage caused by the aging process, such as promoting significant increase in hyaluronic acid synthesis (p <0.05) and, in the case of lavender essential oil, promote a significant increase in total collagen (p <0.05). In addition, the essential oils of lavender and rosemary, reduced studying (p <0.05) the activity of the enzyme collagenase. Finally, the results demonstrated that the essentials of lavender, rosemary reduced studying (p <0.05) the secretion of MMP-1, MMP-2 and MMP-9. Conclusion: The results obtained showed decrease on the MMPs expression, increased in the fibroblasts proliferation and stimulated the synthesis of collagen and hyaluronic acid. We suggest that the essential oils of rosemary and lavender can be in cosmetic formulations to prevent aging.
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